Global Wellness’ Shanti Therapeutics Appoints Renowned Dr. Michael Keane to the Team Update on Clinical Trials

Vancouver, British Columbia, November 1, 2021 – Global Wellness Strategies Inc. (CSE:GWS) (Frankfurt:O3X4) (OTCQB: PNNRF) (“Global” or the “Company”) updates on study progress, clinical trials and appoints world class Key Opinion Leader (KOL) AssociateProfessor Michael Keane to the team.

Shanti Therapeutics is a first-in-class biotech utilizing the neuromodulation properties of MDMA ^[1]Gamma, , Buck, A., Berthold, T. et al. 3,4-Methylenedioxymethamphetamine (MDMA) Modulates Cortical and Limbic Brain Activity as Measured by [H215O]-PET in Healthy Humans. Neuropsychopharmacol 23, … Continue reading (aka Ecstasy) to pre- emptively treat preoperative pain. It has been well researched that the psychosocial component of preoperative and surgical pain is significant and can be influenced by the choice of adjunct therapy including anxiolytics. Recently, it has been postulated that pre-emptively psychedeliccompounds may modulate the brain pathways such that the perception of pain is altered^[2]Ramaekers, , Hutten,     N.     et     al. A      low      dose     of     lysergic      acid     diethylamide decreases      pain      … Continue reading which could permanently reduce an individual’s perioperative pain sensation and even postoperative analgesic requirements.

Appointment of our Key Opinion Leader (KOL): Dr. Michael Keane (MBBS FANZCA)

The company has appointed Dr. Keane as our Key Opinion Leader (KOL) to guide our study methodology and choice of efficacy endpoints for the Shanti trials. Associate Professor Michael Keane is a specialist anesthesiologist with academic appointments at Swinburne University and Monash University in Australia. Professor Keane brings two decades of research experience across a widevariety of clinical and scientific disciplines. Additionally, he is the author of multiple MDMA articles, published in peer-reviewedscientific journals.

Path to Clinical Trials Update:

Shanti Therapeutics is commencing a path to their clinical trial in 22 healthy volunteers comparing the pain tolerance threshold in patients who have had exposure to a proprietary dose and formulation of MDMA. This is proof-of- concept, clinical study to gauge the effect size of increase in pain threshold in subjects who have been pre-emptively treated with MDMA. The study protocol is undergoing finalization currently, with HREC (Human Research Ethics Committee) (aka Institutional Review Board) submission tabledfor late November with a view to commence in-human trials in Q1 2022. Both are standard research reviews on proposals involving human participants to ensure that they are ethically acceptable and that approved steps are taken to protect the rights and welfare ofhumans participating as subjects in the trials.

“Opioid-based treatments have been the cornerstone of perioperative pain management for decades and have been associated with side effects such as nausea, constipation and potential opiate addiction. The management of a patient’s post-surgical pain can be oneof the biggest challenges faced by OR physicians. Shanti Therapeutics believes that MDMA could be a first-in-class treatment where it isused to neuromodulate the perioperative pain response.

The Company is extremely pleased with the quick progress of the Shanti team and welcomes Professor Keane to the squad. GlobalWellness is aware that the psychedelic biopharma sector is now becoming a crowded sector, but with the caliber of the Shanti team, which includes acclaimed physician researcher Dr. Sud Agarwal, Shanti is well differentiated.” stated Meris Kott, CEO Global WellnessStrategies.

About Global Wellness Strategies

Global Wellness Strategies is a prospect generator that provides high growth companies with financial, operational, and management assistance in the fast-growing market for wellness consumer products. The focus of the Company is on global wellness, psychedelics, mycology, hemp and CBD, healthcare-related target companies.

For further information visit websites:

www.globalwellnessstrategies.com and www.shantitherapeutics.com

Or Contact Meris Kott CEO 604.484.0355 or email to [email protected]

Further information about the Company is available on www.SEDAR.com under the Company’s profile.

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